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Your Diabetes Centre

About Glanil^®

GLANIL

Glanil is a leading brand of Glibenclamide, manufactured and distributed by Nigerian-German Chemicals, one of Nigeria's leading pharmaceutical companies.

How does it work?

In patients with diabetes mellitus, there is a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood.

Glibenclamide is an antidiabetic medication which is used in those patients with maturity onset or non-insulin dependent diabetes (NIDDM). It works by lowering blood sugar levels by stimulating the production and release of insulin from the pancreas. It also promotes the movement of sugar from the blood into the cells in the body which need it.

These two mechanisms, in conjunction with a diet low in sugar and fat, allow diabetics to control their blood sugar levels more effectively.

Warning

• Avoid drinking large amounts of alcohol when taking this medication

• Blood sugar levels should be checked regularly when taking this medicine

Use with caution in

• Elderly people

• Kidney disease

• Liver disease

Not to be used in case of

• Life long inherited blood diseases which can cause a variety of symptoms, including mental health problems (porphyrias)

This medication should not be taken if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop taking this medication and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be taken during pregnancy or breastfeeding. However, other medicines may be safely taken in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before taking any medicine.

• Control of diabetes mellitus in pregnancy is usually achieved using insulin because it provides a more stable control of blood sugar. Please consult with your doctor.

• Significant amount of this medicine may be present in breast milk. It should not be taken by breast-feeding mothers.

Side-effects

The side effects of any medicine may affect individual people in different ways. Because a side effect is listed here does not mean that all people using that medicine will experience that side effect.

• Headache

• Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain

• Allergic reaction to active ingredient

• Low blood glucose level (hypoglycaemia)

• Weight gain

• Blood disorders

• Skin rashes

• Severe skin rash (erythema multiforme)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

The following drugs may enhance the effects of glibenclamide leading to low sugar levels in the blood:

Aspirin; non-steroidal anti-inflammatory drugs (NSAIDS); sulphonamide antibiotics; co-trimoxazole; ciprofloxacin; warfarin; beta blockers; ACE inhibitors; anabolic steroids; monoamine oxidase inhibitors (MAOIs); antifungals (fluconazole and miconazole); testosterone; clofibrate; phenylbutazone.

The following drugs may reduce the effect of glibenclamide and so may raise blood sugar levels:

Diuretics (loop and thiazide diuretics); corticosteroids; combined oral contraceptives; rifampicin; chlorpromazine.

Glibenclamide may alter the blood thinning effects of warfarin and other coumarins.